Greatest QTc prolongation. Caution in QTc prolongation, recent myocardial Do not administer with promethazine or benztropine due to anticholinergic
promethazine. buprenorphine and promethazine both decrease QTc interval. Avoid or Use Alternate Drug. propafenone.
buprenorphine, long-acting injection and promethazine both decrease QTc interval. For motion sickness, the first dose of promethazine should be taken 30 to 60
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Promethazine. Propafenone, The risk or severity of QTc prolongation
Additive anticholinergic adverse effects may occur. tetrabenazine. tetrabenazine and promethazine both decrease QTc interval. Avoid or Use Alternate Drug. thioridazine. promethazine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug. tranylcypromine. tranylcypromine increases effects of promethazine by Other (see comment).
The safest antiemeitcs from a QTc prolongation perspective are metoclopramide, prochlorperazine, and promethazine. Trimethobenzamide is also an
Promethazine. Promethazine may increase the QTc-prolonging activities of Escitalopram. Propafenone. Propafenone may increase the QTc-prolonging activities
Hydroxyzine, The risk or severity of QTc prolongation can be increased when Promethazine is combined with Hydroxyzine. Hyoscyamine, Promethazine may increase
strains of P. falciparum (both chloroquine Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. promethazine.
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