A small number of clinical trials using various dopaminergic and stimulant drugs for the treatment of major depression and bipolar depression have demonstrated some benefit when combined with standard antidepressant drugs.
Understanding the pathophysiological mechanisms and the respective importance of dopaminergic versus non-dopaminergic pathology underlying depression in patients with PD is critical to address the heterogeneity of PD depression and develop tailored interventions to treat depression at all stages.
Bupropion is an antidepressant medication used to treat depression Dopaminergic drugs (levodopa and amantadine): CNS toxicity can occur when
by D Burmester 2024Certain clinical features of depression seem to involve dopaminergic neurotransmission. Although medications with specific dopaminergic actions
Antiparkinsonian drugs can be classified as dopaminergic and non-dopaminergic drugs. Dopaminergic drugs include levodopa, dopamine agonists
Antiparkinsonian drugs can be classified as dopaminergic and non-dopaminergic drugs. Dopaminergic drugs include levodopa, dopamine agonists, monoamine oxidase
A significant proportion of patients with depression do not respond to classic antidepressants addressing serotonergic or noradrenergic neurotransmission. Certain clinical features of depression seem to involve dopaminergic neurotransmission. Although medications with specific dopaminergic actions a
Previously validated motivation and depression dimensions were derived from the 15-item geriatric depression scale. Dopaminergic neurodegeneration was measured using repeated striatal dopamine transporter imaging. We identified dissociable associations between dopaminergic medications and different dimensions of depression in PD.
Apathy and anhedonia, both disorders of motivation which share cognitive mechanisms, are prominent in depression in PD, correlate with loss of dopaminergic projections to the striatum and are responsive to dopaminergic medication.
Comments
You wrote, Maybe one day, he would find someone who could truly love all of him. Sadly, I think it is impossible for a depressed man because he cannot truly love all of himself. Depression is often a terminal disease.