Omeprazole and methotrexate
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The serum concentration of Methotrexate can be increased when it is combined with Omeprazole. Metabolizes methotrexate (MTX) to polyglutamates.
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Omeprazole taken with clopidogrel can lower the activity of clopidogrel, so avoid taking these drugs together. Taking omeprazole with methotrexate may result in high levels of methotrexate or methotrexate toxicity. Your doctor may temporarily stop omeprazole treatment if you are taking a high dose of methotrexate.
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Clopidogrel: omeprazole reduces effectiveness of clopidogrel. Omeprazole and clopidogrel are metabolised by the same enzyme (CYP2C19). 10; Methotrexate: omeprazole increases exposure to methotrexate as it inhibits renal elimination of methotrexate. 11; Lansoprazole Indications. Like omeprazole, lansoprazole is another type of proton pump inhibitor.
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Hepatic insufficiency: − Omeprazole: In − Methotrexate - PPIs possibly reduce excretion of methotrexate, leading to an increased risk.
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PRILOSEC (omeprazole) Delayed-Release Capsules and PRILOSEC. (omeprazole Methotrexate: PRILOSEC may increase serum levels of methotrexate. (7.7).
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Omeprazole taken with clopidogrel can lower the activity of clopidogrel, so avoid taking these drugs together. Taking omeprazole with methotrexate may result in high levels of methotrexate or methotrexate toxicity. Your doctor may temporarily stop omeprazole treatment if you are taking a high dose of methotrexate.
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What is Omeprazole? Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,462 Omeprazole users for its effectiveness, alternative drugs and more. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.
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Methotrexate 2.5 mg Tablets (methotrexate) must only be taken once a week. There is evidence that co-administration of methotrexate and omeprazole prolongs
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Omeprazole and Methotrexate. Omeprazole can increase the blood levels and side effects of methotrexate. Concomitant use of the two drugs may elevate and prolong serum concentrations of methotrexate and its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. Omeprazole and Clopidogrel (Plavix)
Hence Omeprazole being a much more expensive drug than it is now.....