Amlodipine 5 mg and simvastatin 20 mg
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Management: Dose of simvastatin should not exceed 20 mg daily if coadministering with amlodipine. If coadministering with simvastatin and amlodipine, close
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Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin; Limit simvastatin dose in patients on amlodipine 20 mg/day
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Each tablet contains amlodipine besilate equivalent to 5 mg of amlodipine. For simvastatin in patients on amlodipine to 20 mg daily. In clinical
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Use of amlodipine 5 mg with simvastatin 5 mg resulted in a proportionally smaller increase in simvastatin plasma concentration. Similarly
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Use of amlodipine 5 mg with simvastatin 5 mg resulted in a proportionally smaller increase in simvastatin plasma concentration. Similarly
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The 2.5 mg dose cannot be obtained with Amlodipine tablets 5 mg as these tablets Limit the dose of simvastatin in patients on Amlodipine to 20 mg daily. In
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Use of amlodipine 5 mg with simvastatin 5 mg resulted in a proportionally smaller increase in simvastatin plasma concentration. Similarly
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- 5 mg of amlodipine (as amlodipine besylate) and 80 mg of It is recommended to limit the dose of simvastatin to 20 mg daily in patients on amlodipine.
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Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.
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