Cyanide toxicity nitroprusside

Toxicity. The toxicity of nitroprusside is related to its potent antihypertensive effects and the accumulation of toxic metabolites (cyanide, thiocyanate, and methemoglobin). 1. Cyanide toxicity: Nitroprusside combines with hemoglobin and is subsequently metabolized to 5 cyanide ions and cyanmethemoglobin. Cyanide then converts to thiocyanate

The incidence of nitroprusside-induced cyanide toxicity is unknown but is likely less than 2.5% . Nonetheless, the risk is serious because diagnosis can be challenging. We present a case of nitroprusside-induced cyanide toxicity after cardiac surgery, with delayed manifestation hours after discontinuation of nitroprusside infusion.

Sodium nitroprusside and cyanide: comparative toxicity The authors review 48 references from the literature and conclude that the use of Sodium Nitroprusside

An early manifestation of cyanide toxicity is increasing dosage requirements to maintain blood pressure control. Metabolic acidosis may not be evident for more than an hour after toxic cyanide levels accumulate. If cyanide toxicity develops, discontinue sodium nitroprusside, and consider specific treatment of cyanide toxicity [see Overdosage

SODIUM NITROPRUSSIDE STRENGTHENED CYANIDE TOXICITY WARNING has been adopted by Abbott and Hoffmann-La Roche, marketers of sodium nitroprusside under the

Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.

Antidote Chart ; Cyanide Antidote Kit (Nithiodote by Hope Pharmaceuticals). Cyanide sodium nitroprusside toxicity. Conventional cyanide antidote

cyanide toxicity or as thiocyanate toxicity. o Standard Cyanide treatment is often effective. Sodium nitroprusside infusions at rates

Infants are particularly susceptible to cyanide toxicity. If signs of cyanide toxicity appear: Discontinue sodium nitroprusside infusion. Consult Poisons