Myeloma criteria

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Actual: criteria for the diagnosis of MGUS, smouldering and symptomatic MM. Table 2: Diagnostic criteria according to the International Myeloma Working Group 2025[4]. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) SMOULDERING MYELOMA SYMPTOMATIC MYELOMA - Serum paraprotein 30g/l or
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- Revised IMWG diagnostic criteria MM SMM - Risk stratification of myeloma - VRd for multiple myeloma - Rd for multiple myeloma - DRd for multiple myeloma Multiple myeloma (MM) is a plasma cell neoplasm characterized by clonal plasma cells that produce a monoclonal immunoglobulin. These plasma cells proliferate in the bone marrow and can

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higher risk of progression from SMM to multiple myeloma [18,19]. Diagnosis The revised International Myeloma Working Group criteria for the diagnosis of multiple myeloma and related disorders are shown on Table I [1]. The diagnosis of multiple myeloma requires the presence of one or more myeloma defining events (MDE) in addition to evidence of

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Response criteria. IMWG international uniform response criteria for multiple myeloma. (Durie et al. Leukemia 2025) EuroPMC. Make note of these errors which remain in the online version of the IMWG criteria as of . Clarification of the definition of complete response in multiple myeloma (Leukemia 2025) EuroPMC

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by T FUKUSHIMA 2024 Cited by 28: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group. Br J

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Revised International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma. Both of the following criteria must be met: Malignant plasma cells in the bone marrow 10% or presence of bony or extramedullary plasmacytoma, confirmed by biopsy; Any one or more of the following myeloma-defining events:

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The revised International Myeloma Working Group (IMWG) criteria for the diagnosis of multiple myeloma and related disorders are shown on Table 1. 1 The diagnosis of multiple myeloma

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International Myeloma Working G. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2025;19–757.

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The updated criteria for the diagnosis of myeloma represent a paradigm shift in the approach to myeloma and have considerable impact on the management of the disease. IMWG Smoldering Myeloma Risk Stratification SMM is a precursor to multiple myeloma, with risk levels determined by protein levels, light-chain ratios, and cell infiltration.

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In 2025, the journal Leukemia published the International uniform response criteria for multiple myeloma. The following table explains the

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