Folic acid antagonist drugs
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As trimethoprim is a folic acid antagonist, there are concerns that periconceptual/perinatal use may limit the availability of folic acid and impact the
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Folic Acid Antagonists Acid Antagonists, Folic Antagonists, Folic Acid Dihydrofolate Reductase Inhibitors Inhibitors, Dihydrofolate Reductase Reductase
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A type of drug that stops cells from using folic acid to make DNA and may kill cancer cells. Certain folic acid antagonists are used to treat some types of cancer and inflammatory conditions, such as rheumatoid arthritis. Also called antifolate and folate antagonist.
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1) Neutralising the immediate toxic effects of folic acid antagonists, e.g, Methotrexate. 2) Calcium Folinate Rescue - a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g, methotrexate, to minimise systemic toxicity.
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Drugs in the category include methotrexate and 5-fluorouracil (folic acid antagonists); azathioprine, mercaptopurine, and 6-thioguanine (purine antagonists);
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Methotrexate is a folate antagonist. Methotrexate inhibits dihydrofolate reductase (DHFR), the enzyme that reduces folic acid to tetrahydrofolic acid.
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Sulfamethoxazole/Trimethoprim Micromedex by Merative Drug Classes:Antibiotic, Sulfonamide, Folic Acid Antagonist, Anti-Infective Agent, Sulfonamide Combination
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Sulfamethoxazole/Trimethoprim Micromedex by Merative Drug Classes:Antibiotic, Sulfonamide, Folic Acid Antagonist, Anti-Infective Agent, Sulfonamide Combination
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by ZM Balaiyawala 2024The classes of antimetabolite drugs included in this discussion are purine antagonists, pyrimidine antagonists, folic acid antagonists, thymidylate synthase (TS)
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Of course, it’s probable that I’m wrong - but, I’m not going to peek at the “other place”, to see if I was right or not! I’m content to wait until Chapter 9 and find out, like everyone else :-)