Acyclovir nephrotoxicity

acyclovir-induced nephrotoxicity. Additionally, risk factors for the development of nephrotoxicity, including the effect of obesity and dosing strategy, were assessed. RESULTS: One hundred fifteen patients were included in the study. A total of 24 (21%) patients developed nephrotoxicity after acyclovir exposure and

Nephrotoxicity is the AE related to acyclovir exposure that is most concerning. 12 Damage to the renal tubules is thought to occur when acyclovir crystals precipitate leading to an obstructive nephropathy. 12 A retrospective case-control study of 373 infants and children treated with intravenous acyclovir found that nephrotoxicity defined as

Acyclovir can cause neurotoxicity and nephrotoxicity, especially in diabetic patients with renal impairment. Consider acyclovir dose adjustment

acyclovir is discontinued. It is likely that most cases of acyclovir nephrotoxicity, which is likely due in part to direct tubular toxicity

Enter a drug name to check for any interactions. amikacin. No Results acyclovir. acyclovir and amikacin both increase nephrotoxicity and/or

Most common adverse drug reactions associated with systemic acyclovir therapy include nephrotoxicity and neurological complications. Acyclovir is commonly

acyclovir. acyclovir and streptomycin both increase nephrotoxicity and/or does NOT have all possible information about this product. This

The case described in this vignette is an example of the clinical manifestation of acyclovir crystal obstructive nephrotoxicity. We will briefly discuss the pathophysiology, diagnosis, prevention, and management of patients that present with acyclovir nephrotoxicity.

What is Known: Although acyclovir is mostly well tolerated, nephrotoxicity may be seen due to the accumulation of acyclovir crystals in renal tubules. Older age, obesity, and concomitant use of other nephrotoxic drugs are reported to be risk factors for acyclovir-induced AKI in children.