Due to the absence of extra-hepatic removal, IC-GREEN was found to be suited for serial study of severe chronic liver disease and to provide a stable measurement of hepatic blood flow. In larger doses, IC-GREEN can be used in detecting drug-induced alterations of hepatic function and in the detection of mild liver injury.
1,1-dimethyl-3-(4-sulfobutyl)-1Hbenz[e]indolium hydroxide, inner salt, sodium salt. IC-GREEN has a pH pf approximately 6.5 when reconstituted. Each vial of IC-GREEN contains 25 mg of indocyanine green as a sterile lyophilized powder. Clinical Pharmacology: Following intravenous injection, IC-GREEN is rapidly bound to plasma
CLINICAL PHARMACOLOGY Following intravenous injection, IC‑GREEN is rapidly bound to plasma protein, of which albumin is the principle carrier (95%). IC‑GREEN undergoes no significant extrahepatic or enterohepatic circulation; simultaneous arterial and venous blood estimations have shown negligible renal, peripheral, lung or cerebro‑spinal uptake of the dye.
IC-GREEN is a sterile, lyophilized green powder containing 25 mg of indocyanine green with no more than 5% sodium iodide.
use IC-GREEN safely and effectively. See full prescribing information for IC-GREEN . IC-GREEN (indocyanine green for injection, USP) For Intravenous Injection Initial U.S. Approval: INIDICATION AND USAGE-IC-GREEN a tricarbocyanine dye, is indicated: For determining cardiac output, hepatic function and liver
The usual doses of IC-GREEN for dilution curves are: Adults 5.0 mg, Children - 2.5 mg, and Infants - 1.25 mg. Hepatic Function Studies. Under sterile conditions, the IC-GREEN powder should be dissolved with the Sterile Water for Injection, USP provided. The patient should be weighed and the dosage calculated on the basis of 0.5 mg/kg of
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Dosages up to 40 mg IC-GREEN dye in 2 mL of aqueous solvent have been found to give optimal angiograms, depending on the imaging equipment and technique used. The antecubital vein injected IC-GREEN dye bolus should immediately be followed by a 5 mL bolus of normal saline.
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